Hwang et al. have demonstrated that the transcription of SELENOM is inhibited in a significant manner in the brains of familial AD transgenic mice overexpressing a human mutant presenilin 2 (PS2) gene, which disrupts Ca2+ homeostasis by facilitating the transfer of Ca2+ from the endoplasmic reticulum to mitochondria [131]. This evidence concerns the gene SELENOM and Alzheimer disease.