Cancer cells, CAFs, and TAMs driven by hypoxia, collectively alter the ECM within the TME by increasing the accumulation of biophysical components such as collagens and enhancing cross-linking through enzymes from the Lysyl Oxidase (LOX) family, including LOX-1, LOXL-2, and transglutaminase enzymes like transglutaminase-2 [111,112]. This evidence concerns the gene LOX and cancer.