Similarly, 3xTg-AD mice treated with CN exhibited lower labeled areas for glial fibrillary acidic protein (GFAP) (p = 0.017) and ionized calcium-binding adapter molecule 1 (Iba-1) (p = 0.019) in the same region compared with the vehicle group (Figure 7I,M). This evidence concerns the gene AIF1 and Alzheimer disease.