MAPT and Alzheimer disease: Therefore, AD emerges from an overproduction and accumulation of Aβ peptides that eventually propitiates the aggregation phenomena of their monomers [14], which trigger a variety of alterations, like disruption of synaptic plasticity, induction of tau-pathology, neuroinflammation, mitochondrial dysfunction and oxidative stress, alterations in neurotransmitter signaling, and deterioration of brain networks [15].