Before transplantation, the concentration of FGF21 differed significantly between AIH and HBV (p = 0.046), HCV and ALD (p = 0.049), HCV and PSC (p = 0.027), HCV and HBV (p < 0.0001), and HBV and HCC (p = 0.0017). Here, FGF21 is linked to hepatocellular carcinoma.