Second, topical application of CTE attenuated HDM-induced AD symptoms, including dermatitis score, dorsal skin and ear epidermal thickness; plasma histamine, CCL17, CCL22, corticosterone, and cortisol levels; lesional TSLP, CD4+ T cells, IL-4, ICAM-1 expression; and infiltration of inflammatory cells into the lesions. This evidence concerns the gene ICAM1 and skin disorder.