Recent studies identified miRNAs such as miR-373-5p and miR-1276 in colorectal cancer and miR-374a in breast cancer, which bind to the 3′-UTR of LACTB mRNA, suppressing its translation, reducing protein levels, and impairing its tumor-suppressive functions (Figure 2b) [13,16,17]. The gene discussed is LACTB; the disease is breast carcinoma.