In nasopharyngeal carcinoma cells, LACTB upregulation increases receptor tyrosine protein kinase erbB-3 (ERBB3) expression, which dimerizes with epidermal growth factor receptor (EGFR) to activate downstream mitogen-activated protein kinase (MAPK) and RAC serine/threonine protein kinase (AKT) signaling pathways. The gene discussed is ERBB3; the disease is nasopharyngeal carcinoma.