In liver cancer cells, LACTB overexpression also prolongs the half-life and nuclear localization of p53; however, in contrast to colorectal cancer, stabilized p53 in liver cancer promotes ferroptosis by directly binding to the heat shock protein family A (Hsp70) member 8 (HSPA8) promoter and reducing HSPA8 expression [28]. This evidence concerns the gene HSPA8 and colorectal cancer.