Research on LACTB in cancers such as breast cancer, bladder cancer, gastric cancer, and melanoma has consistently demonstrated its profound impact on mitochondrial function (Figure 3), inducing mitochondrial depolarization in cancer cells and significantly affecting mitochondrial respiration, Δψm, ATP production, and ROS-related cellular damage [14,15,22,26,40]. This evidence concerns the gene LACTB and urinary bladder cancer.