Conversely, PhM, as well as concurrent administration of MH or ZC with AlCl3, significantly raised the brain level of Wnt3a by 2.9-, 5-, and 5.3-fold and β-Catenin by 3.8-, 5.3-, and 5.3-fold, respectively, as opposed to the AD group. This evidence concerns the gene WNT3A and Alzheimer disease.