However, we intended to carry out a more thorough analysis and look into the molecular basis underlying AlCl3-induced AD and the potential neuroprotection of MH and ZC in combination with PhM; therefore, we endeavored to explore the impacts of different signaling pathways in the afforded neuroprotection such as Nrf2/HO-1/GPX4, ferroptosis, TLR4/NF-kB/NLRP3 inflammasomes, Wnt3/β-catenin/GSK-3β, and ApoE4/LRP1. Here, APOE is linked to Alzheimer disease.