It is noteworthy that MyoD gene transfer lessens survival and facilitates motor neuron degeneration and muscle denervation in the G93A SOD1 fALS mouse model [25], most likely due to the inhibitory function of MyoD on still-available functional Piezo2 and the facilitation of the already depleted regenerative capacity in ALS. Here, PIEZO2 is linked to amyotrophic lateral sclerosis.