PIEZO2 and amyotrophic lateral sclerosis: The Piezo2-containing proprioceptive large fibers are also suggested to provide proton-tunneled ultrafast mechanosensory feedback to motoneurons through vesicular glutamate transporter 1 (VGLUT1) (Figure 1) [4], and that is theorized to be transiently impaired in DOMS and come to an end in ALS [4].