PIEZO2 and amyotrophic lateral sclerosis: Over and above, it seems that dysfunctional Piezo2-induced impaired proton signaling contributes to mechanical sensitization and pain, even more so in the mechanical hyperalgesia of DOMS in a bi-phasic and bi-compartmental manner, but it appears that the progressive degenerative complete loss of this likely principal and vital Piezo2-initiated proton-based neurotransmission is also the proposed gateway to ALS pathophysiology [4].