Since TMEM120A/TACAN is capable of regulating gene expression [24], like MyoD is a myogenic transcription factor involved in early regeneration [25], and Piezo2 channelopathy is proposed to be a principal transcription activator [4], the current author suggests that linoleic acid stabilizes the functional protein–lipid interaction of Piezo2. Here, PIEZO2 is linked to channelopathy.