PIEZO2 and amyotrophic lateral sclerosis: It is notable that the progressive degenerative irreversible type of acquired Piezo2 channelopathy at proprioceptive terminals is suggested to be the gateway to pathophysiology in amyotrophic lateral sclerosis (ALS) where this proposed WDR activation mechanism is abrogated due to the theorized irreversibly lost Piezo2 function [4].