CD8+T cells are characterized by a highly expressed CD161, while its ligand LLT1 (CLEC2D) is expressed in TCs, so the LLT1/CD161 distribution pattern is characterized by a high proportion of LLT1+ TCs and a low proportion of CD161+ CD8+T cells and is associated with a higher risk of lymph node metastasis [73]. Here, KLRB1 is linked to metastatic malignant neoplasm in the lymph nodes.