Among DRG neurons of mice with osteosarcoma femur implantation, TRPV1 were shown to be co-localized with CGRP, a marker of peptidergic neurons, and the neurofilament 200 kD (NF200), a marker of neurons with myelinated fibres, but not with isolectin B4 (IB4), which is a marker of nonpeptidergic unmyelinated neuron [106]. This evidence concerns the gene TRPV1 and osteosarcoma.