Quercetin inhibits expressions of several molecules within the PAR2/TRPV1 pathway, namely PAR2, TRPV1, PKA, and PKC-γ in the DRG neurons in rats with bone cancer pain, as well as inflammatory mediators and cells, such as TNF-α, IL-1β, and macrophages, thus hindering the peripheral and central sensitization of bone cancer pain. This evidence concerns the gene F2RL1 and bone neoplasm.