Nonetheless, after implantation of mammary rat metastasis tumour (MRMT-1) tumour cells into the tibial canal in rats, Zheng et al. found that cancer-induced thermal and mechanical hyperalgesia were correlated with the amplified excitability of small-sized TRPV1- and IB4-positive DRG neurons [53]. The gene discussed is TRPV1; the disease is neoplasm.