A subcutaneous injection of squamous cell carcinoma (SCC-7) [176], SCC-158 cells [177], or osteosarcoma NCTC 2472 cells [170] in animals caused heat hyperalgesia and higher TRPV1 expression in DRG, which were reduced via the administration of capsazepine (CPZ). The gene discussed is TRPV1; the disease is osteosarcoma.