In alcohol-exposed mice, 11 proteins associated with AD, including hexokinase-1 (HK1), syntaxin-binding protein 1 (STXBP), and brain-abundant membrane-attached signal protein 1 (BASP) were found in the amygdala and 12 proteins associated with AD such as ATP synthase F1 subunit delta (ATP5D), enolase 2 (ENO2), and amphiphysin (AMP) were found in the prefrontal cortex. This evidence concerns the gene HK1 and Alzheimer disease.