PSEN1 and Alzheimer disease: Results of a recent study on a murine model of AD (APP/PS1) and young wild-type mice comparing the effects of 7 hours of sleep deprivation showed that the inability of APP/PS1 mice to enhance norepinephrine oscillations following sleep deprivation may contribute to glymphatic dysfunction, increased vulnerability to sleep loss, and subsequent Aβ buildup, which is also supported by proteome analysis showing altered protein clearance [27].