MAPT and Alzheimer disease: In a genome-wide association analysis comprising 3046 participants from 12 different studies, Nho et al. have found novel genetic variants in cytochrome P450 1B1 (CYP1B1)-RMDN2 locus that affect medial temporal lobe and cortical tau levels measured by PET, shedding light on the genetic underpinnings of cerebral tau deposition and supporting novel pathways for therapeutic developments in AD [55].