SDC1 and aneurysm: Likewise, Xiao et al., through the administration of elastin and angiotensin II in SDC 1−/− mice, highlighted during aneurysm formation an increase in macrophages associated with SDC-1, an increase in proteolytic activity, with an increase in MMP-9 and MMP-2 within the aortic wall and, furthermore, the reduction in the expression of IL-10 and Foxp3 demonstrates how the deficit of SDC 1 determines a reduction in the ability to limit the inflammatory process [32].