In particular, Wen and colleagues studied the expression of SDC-1, -2, -4 using 8-week-old male Apo-E-deficient mice (mice subjected to an atherogenic diet), before and after the stimulation of arterial hypertension by the infusion of angiotensin II with the aim of inducing the formation of aortic aneurysms. Here, APOE is linked to aortic aneurysm.