MAPK8 and liver cancer: In line with our findings, we should highlight here that previous reports have demonstrated the synergistic effect of the combination of irradiation and JNK inhibition by SP600125 in vivo using Lewis lung carcinoma and mouse models, with subcutaneous xenograft or intracranial [41,42], and using patient-derived vestibular schwannoma cells [43] and in vitro using liver cancer HepG2 cells [44].