Specific NRs, such as the peroxisome proliferator-activated receptors (PPARs), retinoid X receptor (RXR), and estrogen receptors (ERs), have been shown to affect Aβ metabolism, tau phosphorylation, and neuroinflammatory pathways, all of which are central to AD pathology [25,26]. The gene discussed is ESR1; the disease is Alzheimer disease.