It has been reported that the recombinant nuclear receptor related protein 1 (Nurr1) monomer was directly interacted with p65 on the response elements of nuclear factor kappa-B (NF-κB) during the polymerization process to recruit the CoREST co-suppressor complex, thereby inhibiting the expression of pro-inflammatory genes regulated by NF-κB and reducing neuroinflammation in AD [46]. Here, NR4A2 is linked to Alzheimer disease.