SIRT1 and Alzheimer disease: Qu et al. found that the elevated expression levels of orphan NR tailless-like protein (TLX) were accompanied by the upregulation of Sirtuin 1 (SIRT1) and downregulation of inflammatory cytokines, suggesting that TLX can block the development of AD by regulating the SIRT1/NF-κB pathway, promoting hippocampal neurogenesis, and inhibiting neuroinflammatory responses [77].