Chen et al. [169] observed the therapeutic effects of mineralocorticoid receptor antagonists on Aβ-induced cognitive deficits in mice and found that mineralocorticoid receptor antagonism attenuated cognitive deficits and Aβ deposition and activated the nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent antioxidant system. This evidence concerns the gene NFE2L2 and Cognitive impairment.