Although the rate of SARS-CoV-2 PCR positive tests in the neonates of our study population was nearly zero (except for one neonate), and therefore, there was limited vertical transmission of SARS-CoV-2, the data derived from our study suggest immunological disturbances in this population, related to the recent peripartum exposure to maternal COVID-19, as reflected by the increased concentrations of IP10 in the blood samples obtained from neonates of mothers SARS-CoV-2-positive mothers, compared to the neonates from mothers who were not exposed to the virus. This evidence concerns the gene CXCL10 and COVID-19.