Nonetheless, for PEDV it was observed that cells expressing PEDV Mpro-uncleavable NEMO (NEMO Q231A) only partially restored IFN-β reporter activity upon infection with SeV when Mpro was present [23], which would still point to additional Mpro-mediated effects in the disruption of innate immune responses other than the cleavage of NEMO, warranting further investigation. The gene discussed is IFNB1; the disease is infection.