Using the WES technique, 22 variants in 15 genes associated with Brugada syndrome were identified in 21 patients (34%), including SCN5A, CACNA1S, CACNB2, CASQ2, DLG1, JUP, KCNE1, KCNH2, KCNJ5, KCNQ1, PKP2, SCN10A, DSP, MYBPC3, and LAMA2. This evidence concerns the gene PKP2 and Brugada syndrome.