HMGB1 is released extracellularly from necrotic tumor cells and induces nuclear factor–κB (nuclear factor–kappa-light-chain-enhancer of activated B cells) activation and cytokine production via the receptor’s receptor for glycation end products (RAGE) and toll-like receptor 4 (TLR4) expressed on tumor cells, promoting tumor growth, survival, invasion and metastasis [11,12]. This evidence concerns the gene TLR4 and neoplasm.