The C-type lectin domain family 16, member A protein encoded by CLEC16A is instrumental for autophagic and endosomal processes whereby it affects receptor expression in NK cells and antigen-presenting cells, and T cell selection through modulation of thymic epithelial cells, impacting biological functions of importance for autoimmunity in general [19,20,21,22,23,24,25,26,27,28,29,30]. Here, CLEC16A is linked to Autoimmunity.