Similarly to the lean abnormal phenotype, subjects with obesity abnormal had a significantly higher abundance of potentially harmful bacteria in their gut, accompanied by elevated hs-CRP levels, indicative of gut dysbiosis and systemic inflammation, which may have spilled over into the adipose tissue, as evidenced by the highest plasma levels of leptin, chemerin, IL-18, and MCP-1. The gene discussed is CCL2; the disease is obesity due to melanocortin 4 receptor deficiency.