TNF and Abdominal obesity: Additionally, abdominal obesity and related cardiometabolic risk factors linked to an unhealthy adipose tissue expansion are accompanied by low-grade, chronic, systemic inflammation, linked to overexpressing proinflammatory factors, including chemokines (e.g., MCP-1, MIP-2, CCL5, IL-8, IFN-γ), damage-associated molecular pattern molecules, and cytokines, such as TNF-α, IL-6, and the interleukin-1 family (i.e., IL-1β, IL-18, IL-33, and IL-37) [16,20].