While tumor-specific CD8+ T cells recognize and react to tumor antigens presented on MHC molecules, the bystander CD8+ T cells present in the TME remain in a non-functional state or significantly contribute in the local immunological microenvironment by secreting several cytokines and chemokines in a way that could be beneficial or detrimental to tumor control [30]. The gene discussed is HLA-C; the disease is neoplasm.