In B-cell lymphomas and leukemias, lncRNAs regulate cell death through modulation of Bcl2 family-mediated apoptosis (DLEU1/2, HULC), Fas-mediated apoptosis (FAS-AS1), or by interactions with the p53 pathway during DNA damage response (lincRNA-p21, NEAT1) [17,18,19,20,21,22]. The gene discussed is FAS; the disease is leukemia.