It was shown that lnc-IRF2-3 expression in CLL is positively correlated with the expression of gene sets involved in lipid, amino-acid and sugar metabolism, determination of cell polarity, but also with the gene set associated with the primary immunodeficiency disorders which includes several genes that have pivotal roles in CLL cells’ activation (Bruton tyrosine kinase (BTK), ZAP-70, CD40, CD79A, CD19, etc.)[31]. Here, BTK is linked to B-cell chronic lymphocytic leukemia.