TLR8 and COVID-19: Of note, Made et al. found that loss of function in TLR7 variants is a determinant of and associated with severity and death in COVID-19 patients [27]; furthermore, SNPs in TLR7 and TLR8 have been related to COVID-19 in females (A-allele of the TLR7 rs179009 SNP) and to disease severity and in males (rs3764880) to comorbid diseases [31].