Accordingly, the genes responsible for ADPKD encode proteins that either colocalize to renal tubule epithelia primary cilia (PKD1, PKD2, and IFT140) or assist in their co-translational glycosylation in the endoplasmic reticulum (GANAB, DNJB11, and ALG9). Here, PKD2 is linked to autosomal dominant polycystic kidney disease.