AKT1 and neoplasm: In more detail, genistein-treated CRC cells (SW480), among other phenomena, showed downregulated expressions of TATTY18 and reduced cell migration, coupled to a decrease in glucocorticoid-regulated kinase 1 (SGK1) and reduced Akt and p38-MAPK phosphorylation; these results were confirmed in vivo using genistein-treated tumor-bearing nude mice [118].