MDM2 and breast cancer: Similarly, cell cycle arrest in the G2 phase in response to genistein treatment has been described in BC MCF-7 and PC cell lines (PC3), where genistein downregulated the mouse double minute 2 (MDM2) oncoprotein at the transcriptional level by interacting with the MDM2 promoter and at the post-transcriptional level by inducing MDM2 ubiquitination [188].