High doses of the phytoestrogen (100 μM), by inactivating the FAK/paxillin signaling cascade, inhibited the cell adhesion, migration, and invasion triggering apoptosis; on the contrary, a low dosage of genisetin (12.5–50 μM) significantly promoted both invasion and migration of melanoma cells by activating the FAK/paxillin and MAPK signaling pathways [98]. This evidence concerns the gene PXN and melanoma.