JUN and hepatocellular carcinoma: Wang et al. (2014) observed that genistein blocks TPA-mediated metastasis via the downregulation of MMP-9 and epidermal growth factor receptor (EGFR) followed by the suppression of nuclear factor-κB (NF-κB) and activating protein-1 (AP-1) transcription factors and inhibition of MAPK, IκB, and PI3K/Akt signaling pathways in an HCC model [101].