Moreover, genistein-treated MCF-7, MCF-7-caspase-3 (MCF-7-C3), and T47D BC cells expressed low levels of the cancerous inhibitor of protein phosphatase 2A (CIP2A) which correlated with growth inhibition and apoptosis induction, as evidenced by PARP cleavage and the expression of functional caspase-3 in MCF-7-C3 and T47D [232]. The gene discussed is CASP3; the disease is breast cancer.