For example, an isoflavone mixture (83.3% genistein, 14.6% daidzein, and 0.26% glycitein) inhibited the phosphorylation of Akt and FOXO3a, regulated the phosphorylation of Src, and increased the expression of glycogen synthase kinase-3β (GSK-3β), leading to the downregulation of androgen receptor (AR) and its target gene prostate-specific antigen (PSA) with the result of induction of apoptosis in both androgen-sensitive and -insensitive PC cells [278]. This evidence concerns the gene AR and pachyonychia congenita.