Furthermore, in line with the action of the flavonoid explained above, by using a dedicated multiplex-array assay, Uifalean and co-workers (2018) showed genistein dose-dependently hindered C-X-C motif chemokine ligand 16 (CXCL16) and vascular endothelial growth factor-A (VEGFA) secretion in BC in vitro (in MCF-7 estrogen-dependent and MDA-MB-231 estrogen-independent cell lines) [73]. This evidence concerns the gene VEGFA and breast cancer.