DKK2 and renal carcinoma: In addition, Hirata et al. (2021) demonstrated that isoflavones, by regulating miR-1260b expression, inhibited Wnt signaling effector genes such as secreted frizzled-related protein 1 (sFRP1), Dickkopf 2 (Dkk2), and Smad4 in renal cancer cells (786-O, A-498, Caki-2 cell lines); functionally, cancer cell invasiveness together with proliferation and apoptosis phenomena was significantly decreased [119].