Whole-genome expression analysis showed that the combination of genistein and the histone deacetylase inhibitor vorinostat induced apoptotic cell death by decreasing baculoviral IAP repeat-containing protein 7 (BIRC7/Livin), transforming growth factor beta-1-induced transcript 1 protein (TGFB1I1/ARA55), hairy and enhancer of split-1 (HES1), and Snail family transcriptional repressor 2 (SLUG), which are involved in the TNF-NF-κB and androgen signaling pathways in PC3, DU145, ARCaP-E, ARCaP-M, and LNCaP cancer cell lines [271]. The gene discussed is HES1; the disease is cancer.