FLT4 and colorectal carcinoma: Furthermore, Xiao and co-workers demonstrated that the isoflavone inhibited (in a dose-dependent manner) the invasiveness of human colon–rectal cancer (CRC) cells, as well as metastasis formation in murine orthotopic implantation models, through the selective suppression of the proangiogenic marker Fms-related tyrosine kinase 4 (FLT4) (i.e., VEGFR2) and MMP-2 [86].