As radiotherapy increases the invasive tendency of DNA-PKcs-positive glioblastoma multiforme (GBM), it has recently been shown that genistein can specifically bind to DNA-PKcs, suppressing the DNA-PKcs/Akt2/Rac1 signaling pathway, thereby successfully inhibiting the radiation-induced invasiveness of GBM cells in vitro and in vivo [114]. This evidence concerns the gene RAC1 and glioblastoma.