AKT1 and cancer: Typically, genistein has been shown to inhibit the growth of MCF-7 cells and promote the apoptotic pathway through the inactivation of PI3K/Akt signaling, as evidenced by the decrease in phospho-Akt in treated cells, resulting in reduced expression of the downstream target HOX Antisense Intergenic RNA (HOTAIR) [234], a long ncRNA (lncRNA) implicated in cancer invasion and metastasis [235].