For example, a mixture of genistein and retinoic acid (ATRA) significantly inhibits the invasion ability of human adenocarcinoma cells (A549 cell line) by downregulating the transmembrane protein mucin 1 (MUC1) as well as intercellular adhesion molecules-1 (ICAM1) expression [126]. This evidence concerns the gene ICAM1 and adenocarcinoma.