AR and pachyonychia congenita: Genistein combined polysaccharide (GCP), a dietary supplement containing the isoflavones genistein, daidzein, and glycitein, mediated growth inhibition and apoptosis of PC cells by multiple mechanisms, including molecular mimicry of androgen ablation (via AR downregulation) and by an AR-independent proapoptotic signal (mTOR inhibition) [280].