In this scenario, it has been demonstrated that genistein, by acting on specific signaling pathways (i.e., Sonic Hedgehog (SHH), Wnt/β-catenin, Notch, NF-κB JAK-STAT, PI3K/Akt/mTOR signaling), affects CSC proliferation, thereby inhibiting tumor invasiveness and metastasis (Figure 5) [152]. The gene discussed is NFKB1; the disease is neoplasm.