HIF1A and pachyonychia congenita: However, using dedicated PC cell lines (highly metastatic IA8-ARCaP cells and LNCaP/HIF-1α cells that stably overexpress HIF-1α), Zhang et al. (2008) found that low-dose genistein (0.2–15 μmol/L) inhibited invasion in vitro by reversing the EMT process [141].