Although genistein hurt the efficacy of the aromatase inhibitors letrozole (Let) and anastrozole (Ana), its combination with the aromatase inhibitor Exe potentiated the antiproliferative and apoptotic effect of the single treatment in sensitive (MCF-7-aro) and resistant (LTEDaro) BC cells evidenced by the increase in the ratio of cleaved PARP/PARP [307]. The gene discussed is CYP19A1; the disease is breast cancer.