Lefebvre-Omar et al. [73] studied the impact of Nfl accumulation on MN viability, comparing MNs derived from induced pluripotent stem cells (iPSCs) from patients with mutations in the chromosome 9 open reading frame 72 (C9orf72), superoxide dismutase 1 (SOD1), and TARDBP genes, all of which involved in ALS onset. The gene discussed is NEFL; the disease is amyotrophic lateral sclerosis.