In PD, mutations in PTEN-induced putative kinase 1 (PINK1), E3 ubiquitin ligase (Parkin), or leucine-rich repeat kinase 2 (LRRK2) blunt the elimination of damaged mitochondria, thereby indicating that the PINK1- and Parkin-dependent degradation of Miro is necessary to immobilize damaged mitochondria and address them toward mitophagy [171]. This evidence concerns the gene PRKN and Parkinson disease.