Targeting simultaneously HER2 and PD-1 (margetuximab plus retifanlimab) or HER2 and PD-1 plus LAG-3 (margetuximab plus tebotelimab) enhances anti-tumour activity and the innate or adaptive immune response, with promising potential for patients with unresectable or metastatic GC/GEJC [28]. The gene discussed is PDCD1; the disease is gastric cancer.