Additionally, HLA polymorphisms are associated with severe cutaneous adverse reactions (SCARs), like Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), particularly in Asian populations treated with anticonvulsants such as carbamazepine and oxcarbazepine [100], and phenytoin, which are linked to biomarkers HLA-B*15:02 and HLA-A*31:01 [101]. The gene discussed is HLA-B; the disease is toxic epidermal necrolysis.