IKZF1 and precursor B-cell acute lymphoblastic leukemia: Within CK2 targets, an important role is played by the transcription factor IKZF1 that acts as a tumor suppressor in T- and B-ALL; genome-wide analyses have shown that 30% of pediatric B-ALL and approximately 5% of T-ALL present a deletion or dysfunction of the IKZF1 gene [9,10].