IKZF1 and precursor B-cell acute lymphoblastic leukemia: Mutations that lead to reduced IKZF1 function or expression have also been found to be a major genetic feature in human B-ALL [9] and loss of IKZF1 also promotes the development of T-cell lymphoma/leukemia in mice, which suggests that IKZF1 acts as a tumor suppressor in T- and B-ALL [9,10].