EGFR and malignant colon neoplasm: Particularly, TBLF induces apoptosis in colon cancer cells in a differential manner [7], and such an effect was also observed for rTBL-1, where it was possible to determine the interaction with the epidermal growth factor receptor (EGFR) [13], which is one of the main targets on several cancers due to its glycosylation being related to cancer progression [35].