However, the list of downregulated genes (PPARGC1B, EIF4E3 and SMAD9) was input to breast cancer patients (1889 patients) with 687 low-expression patients and 1202 high-expression patients and a cut-off value for the gene expression of 209.88; colon cancer (1167 patients) with 863 low-expression patients, 304 high-expression patients and a cut-off value for the gene expression of 511; and lung cancer patients (874 patients) with 613 low-expression patients and 261 high-expression patients and a cut-off value for the gene expression of 335. The gene discussed is SMAD9; the disease is colonic neoplasm.