Nicotine and EGF induce genes, including GSPT1, to promote the proliferation, invasion, and migration of non-small cell lung cancers, thus enhancing their tumorigenic activity and revealing the central role of the inhibitor of DNA binding/differentiation 1 (ID1) and its downstream targets in facilitating lung cancer progression [28]. Here, GSPT1 is linked to non-small cell lung carcinoma.