Of these, 19 secreted CRC markers (DDR1, HSP90AA1, SERPINA1, APLP2, RNASET2, APOA1, THBS1, PTPRF, HSP90B1, CST3, BCAM, KITLG, KRT18, SPINT1, PSAP, FAT1, FAM3C, APOE, and EZR) and 20 secreted LC markers (FDPS, IGFBP3, GSTP1, IGFBP2, AKR1B1, NAP1L1, CP, CLU, EFNA1, UCHL1, ALCAM, PSAT1, CTSL, CANX, FSCN1, PGK1, VIM, P4HB, TIMP1, and GAPDH) are involved in metastasis and tumor progression according to the DisGenNET database (Figure S8). Here, RNASET2 is linked to neoplasm.