Of these, 19 secreted CRC markers (DDR1, HSP90AA1, SERPINA1, APLP2, RNASET2, APOA1, THBS1, PTPRF, HSP90B1, CST3, BCAM, KITLG, KRT18, SPINT1, PSAP, FAT1, FAM3C, APOE, and EZR) and 20 secreted LC markers (FDPS, IGFBP3, GSTP1, IGFBP2, AKR1B1, NAP1L1, CP, CLU, EFNA1, UCHL1, ALCAM, PSAT1, CTSL, CANX, FSCN1, PGK1, VIM, P4HB, TIMP1, and GAPDH) are involved in metastasis and tumor progression according to the DisGenNET database (Figure S8). The gene discussed is IGFBP3; the disease is colorectal carcinoma.