SERPINA1 and colorectal carcinoma: The CRC marker protein SERPINA1, detected in the cell models in the present study, was determined to be at a level of 31.2 ± 12.0 fmol/μg in all EVs isolated from patients with CRC and at a level of 22.1 ± 10.7 fmol/μg in all EV samples isolated from healthy volunteers.