ADGRG6 and colorectal carcinoma: The top five proteins that were most significantly increased in the lung-derived EV samples (FC > 5) compared to the CRC cell line-derived EV proteome included UCHL1 (FC = 4.1), GPR126 (FC = 3.7), BASP1 (FC = 3.6), DSC1 (FC = 2.8), and GAPDH (FC = 2.2).