The abundance of 17 proteins (BASP1, CFH, CLEC11A, CLU, CNP, DSC1, GAPDH, GPR126, IGFBP2, IGFBP3, LTF, NAP1L1, P4HB, TIMP1, TKT, UCHL1, and VIM) was higher in the LC cell-derived EVs (A549, NCI-H23, and NCI-H460) as compared to the intestinal EVs (Table S1, sheet ‘LC and CRC secreted markers’). Here, CNP is linked to colorectal carcinoma.