The abundance of 12 proteins (APOA1, APOE, BCAM, CST3, FAT1, GANAB, HIST1H4A, HIST2H3PS2, HSP90B1, KRT18, SERPINA1, and THBS1) was higher in the EV isolated from CRC cell lines (Caco-2, HT29, and HCT116) compared to the EV of lung origin (Table S1, sheet ‘LC and CRC secreted markers’). The gene discussed is CST3; the disease is colorectal carcinoma.