The five proteins UCHL1 (FC = 39.9), C1S (FC = 10.4), CTBS (FC = 8.5), NAGA (FC = 3.1), and PROCR (FC = 9.2) were the most significantly upregulated in the secretome samples of lung origin as compared to the secretome samples derived from CRC cell lines (listed in order of decreasing significance). This evidence concerns the gene PROCR and colorectal carcinoma.