SAMD3 and Miyoshi myopathy: To estimate the mechanisms underlying the effects on cellular metabolic functions and levels of ROS in A375 cells by antidiabetic reagents, pharmacological inhibition of FABPs and MITF and knockdown of ANGPTL4, mRNA expression levels of possible factors related to mitochondrial function and MM pathogenesis, including PGC1α, HIF1α, SAMD3, TRIB3 and ANGPTL4, were evaluated by qPCR analysis.