The purpose of the present study was to elucidate the unidentified effects of the antidiabetic agents immeglimin (Ime) and metformin (Met), FABP family proteins, ANGPTL4 and MITF on biological aspects including the diabetic states of MM, as assessed by evaluating the high-glucose-induced metabolic and redox alterations in melanoma A375 cells. This evidence concerns the gene MITF and melanoma.