Paclitaxel, docetaxel, tamoxifen, cisplatin, mitoxantrone, flutamide, and gemcitabine, the agents used in cancer chemotherapy, are metabolized by CYP1B1 [24,25,26,27], which is overexpressed in extrahepatic cancer tissues, including cancers of the breast, colon, lung, esophagus, skin, lymph node, brain, and testis [28]. This evidence concerns the gene CYP1B1 and cancer.