Integrating these findings with ST, the study found multiple regulatory networks that drive the tissue remodeling process post-myocardial infarction, identifying important transcription factors such as myocyte enhancer factor 2D (MEF2D) and nuclear receptor subfamily 3 group C member 2 (NR3C2) that regulate cardiomyocyte stress states and runt-related transcription factor 1 (RUNX1) in fibroblast activation. Here, RUNX1 is linked to myocardial infarction.