The pan-cancer phenomenon of non-B Lymphocyte immunoglobulin (Ig V[D]J DNA Rearrangements) and immunoglobulin synthesis in de novo emergent cancer cells of diverse epithelial origins is also consistent with a model of “dysregulated AID/APOBEC and ADAR driven RT Ig-SHM-like mutagenesis” across the pan-cancer genome. The gene discussed is AICDA; the disease is cancer.