TARDBP and amyotrophic lateral sclerosis: Mutations in SOD1 (Copper-zinc superoxide dismutase 1) [71], TDP-43 (the gene encoding transactive response DNA binding-protein 43 kDa) [72,73] and FUS (fused in sarcoma) [74,75] have been linked to ALS [76,77,78,79,80,81,82,83,84,85,86,87,88].