A case-control study of the Chinese Han population (296 cases, 320 controls) showed an association of the pathogenesis of schizophrenia with SNPs of the NEDD4 gene at two loci (rs3088077 and rs2303579), while cognitive dysfunctions were associated with SNPs in the NEDD4 gene at two other loci (rs2303579 and rs62043855) [68]. This evidence concerns the gene NEDD4 and schizophrenia.