Another investigation (392 cases, 572 controls) observed that combinations of SNPs in the RNF4 (RING finger protein 4) gene (rs1203860 and rs2282765) and in the SART3 (squamous cell carcinoma antigen recognized by T cells 3) gene (rs2287550) were associated with an increased risk of schizophrenia [70]. The gene discussed is RNF4; the disease is schizophrenia.