CX3CL1 and early-onset autosomal dominant Alzheimer disease: This fact, in addition to supporting the apparent decline of CX3CL1 accumulation paralleling the progression of the disease described above, may highlight the relevance of carefully considering the degree of neurodegeneration in these analyses, because the lack of sufficient intermediate cases or the inaccurate assessment of the degree of degeneration in some of them may prevent the observation of the trend that seems to exist for the production of CX3CL1 in Alzheimer’s disease patients (see summary in Table 1).