CX3CL1 and early-onset autosomal dominant Alzheimer disease: This allowed them to detect an increased concentration of CX3CL1 in the plasma that paralleled the progression of the disease, but only to a certain point, because the levels of CX3CL1 in the most advanced cases of Alzheimer’s disease analyzed, while being higher than those observed in the healthy subjects, were lower than those found in the intermediate stages of the disease [17].