AKT1 and neoplasm: It has been shown in tumor cells that inhibition of p-AKT, p-GSK3β, as well as β-catenin, greatly reduce cell proliferation, migration, and invasion [73], supporting the notion that the reduced formation efficiency and cell viability of sheep intestinal organoids after DON treatment is due to impaired PI3K/AKT/GSK3β and Wnt/β-catenin signaling pathways, at least partially.