The aim of the present study was to evaluate the degree of methylation of the ADAMTS6, ADAMTS9, and ADAMTS12 genes in NSCLC using data from bioinformatics databases, with a particular focus on differences between LUAD (lung adenocarcinoma) and LUSC (lung squamous-cell carcinoma) subtypes and their impact on patient OS (overall survival). The gene discussed is ADAMTS6; the disease is squamous cell lung carcinoma.