The aim of the present study was to evaluate the degree of methylation of the ADAMTS6, ADAMTS9, and ADAMTS12 genes in NSCLC using data from bioinformatics databases, with a particular focus on differences between LUAD (lung adenocarcinoma) and LUSC (lung squamous-cell carcinoma) subtypes and their impact on patient OS (overall survival). This evidence concerns the gene ADAMTS6 and lung adenocarcinoma.