Specifically, CA1 downregulation leads to the acidification of the tumor microenvironment, creating favorable conditions for tumor progression; CCND1 upregulation promotes G1/S phase transition, accelerating tumor cell proliferation; CXCL2 upregulation enhances inflammatory response, remodeling the tumor immune microenvironment; and EIF6 upregulation increases protein synthesis efficiency, supporting rapid tumor cell growth (Figure 2c). Here, EIF6 is linked to neoplasm.