CA1 (Carbonic Anhydrase 1) was downregulated, indicating altered pH regulation in the tumor microenvironment; CCND1 (G1/S-specific Cyclin-D1), CXCL2 (C-X-C Motif Chemokine 2), and EIF6 (Eukaryotic Translation Initiation Factor 6) were upregulated, participating in cell cycle regulation, immune response, and protein synthesis, respectively. This evidence concerns the gene CA1 and neoplasm.