CB1 and CB2 are G-protein coupled receptors implicated in neurogenic and inflammatory pain and itch; they are both expressed on peripheral cutaneous nerve fibers and MCs, so they may influence the recruitment of immune cells and skin inflammation in models of dermatitis, and their agonism showed antipruritic effects at central and peripheral levels in systemic and dermatologic diseases, as well as AD and ACD [106]. Here, CNR2 is linked to dermatitis.