In TAC-induced cardiac hypertrophy in Wistar rats, curcumin (50 mg/kg/day for 9 weeks) improved cardiac function while restoring endothelial function through the upregulation of Na+/Ca2+ exchanger (NCX) and endothelial nitric oxide synthase (eNOS), thereby improving calcium homeostasis and nitric oxide signaling [114]. The gene discussed is NOS3; the disease is cardiac hypertrophy.