NR_027406 (Alias: LOC100129034, a lncRNA) was linked to three mRNAs (INPP4A, PBX1, VPS37A, TPSAB1, SSX1, and PLIN2) and enriched in metabolic pathways, phosphatidylinositol signaling system, Cushing syndrome, transcriptional mis-regulation in cancer, endocytosis, Influenza A, transcriptional mis-regulation in cancer, and PPAR signaling pathway. The gene discussed is PLIN2; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.