We predict that lnc-CLVS2-2 and GARS1-DT might interact with ITGA2, ADH1B, ATG16L1, ISY1, ZNF300, GPR161, and RDH11 in the process of PM2.5-induced lung cell injury through the pathways in cancer, proteoglycans in cancer, focal adhesion, PI3K-Akt signaling pathway, metabolic pathways, chemical carcinogenesis, and PI3K-Akt signaling pathways. This evidence concerns the gene CLVS2 and cancer.