INS and type 2 diabetes mellitus: Currently, three isoforms of this receptor are known: PPAR alpha (PPARα), PPAR beta/delta (PPARβ/δ), and PPAR gamma (PPARγ), which is considered a key molecular target in the control of T2D due to its important role in promoting glucose uptake in peripheral tissues, adipocyte remodeling, and insulin sensitivity, among other metabolic and non-metabolic functions [48].