EGFR and cancer: And finally, another aspect that it is important to know is about the interaction between the integrins and other cell receptors implicated in colonization development, such as α6β4 integrin, which crosslinks with some tyrosine kinase receptors involved in EGFR family members or α5β1 integrin, which can also interact with urokinase-type plasminogen activator receptor to promote proliferation, migration and survival of cancer cells [118].