ITGB4 and neoplasm: Depending on the type of primary tumor, the integrin footprint in EVs can be representative: ITGαvβ6 is involved in prostate, breast, colorectal and lung cancer [92]; ITGβ1 is overexpressed in hepatocarcinoma, related to the activation of the β1-integrin-NF-κB signaling pathway in resident fibroblasts to convert them into CAFs [93]; ITGβ4 and ITGβ5 determine the tropism of EVs to the lung; specifically, ITGβ4 recognizes laminin in the lung parenchyma [11].