AXIN1 and chronic myelogenous leukemia, BCR-ABL1 positive: Regarding hematologic malignancies, it has been shown in vitro that the inhibition of β-catenin through ectopic expression of axin decreases the replating capacity of leukemic cells, suggesting that human chronic myelogenous leukemia (CML) precursors are dependent on Wnt signaling for growth and renewal.