TP53 and cancer: Additionally, this model presents a high conservation of key human cancer-related genes, such as tumor protein p53 (TP53) [16], Kirsten rat sarcoma viral oncogene homolog (KRAS) [17], and vascular endothelial growth factor-A (VEGFA) [18], and critical signaling pathways, including phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) (proliferation) [19], RHOA/Rho-associated protein kinase (ROCK) (migration) [20], and B-cell leukemia/lymphoma 2 protein (BCL2) (cell death) [21].