This model enabled the detailed analysis of EWS-FLI1, revealing its disruption of signaling pathways and the activation of oncogenic drivers like NK2 homeobox 2 (NKX2-2) and myelocytomatosis oncogene (MYC), which are critical for neural development, tumor growth, and invasion [32,174]. The gene discussed is NKX2-2; the disease is neoplasm.