Elevated serum concentrations of ANGPT2 have been observed in patients with multiple myeloma [86], non-small cell lung cancer (NSCLC) [87], metastatic colorectal cancer (CRC) [88], renal cell carcinoma [89], hepatocellular carcinoma [90], and chronic lymphocytic leukemia [91], all of which are associated with a poorer prognosis and rapid disease progression. The gene discussed is ANGPT2; the disease is non-small cell lung carcinoma.