These include integrins, which mediate tumor–ECM adhesion and can be blocked to reduce cancer spread [193,194]; VEGF, which is essential for angiogenesis and studied using zebrafish with fluorescently labeled blood vessels [70,110,195]; TGF-β, which influences EMT and immune evasion [105,196]; EVs, which help to establish pre-metastatic niches [101,197]; and MMPs, which enable tumor invasion by degrading the ECM [50,198]. Here, TGFB1 is linked to cancer.