VEGF-induced vascular leakiness promotes tumor cell extravasation. Hypoxia-triggered angiogenesis drives extravasation. ANGPT2 destabilizes vascular networks by loosening endothelial junctions, facilitating vessel remodeling. CAFs and TAMs induce ECM degradation via MMP2/9 and VEGF, enhancing angiogenesis and tumor cell migration. Here, MMP2 is linked to neoplasm.