Similar ascending profiles were registered for the expression of the NLRP3 inflammasome components, such as Nlrp3, caspase-1, and Il-1β, in the presence of the GFAP + PTX implant compared with the positive control group, suggesting the efficacy of PTX embedded into GFAP scaffolds to initiate pyroptosis tumor cell death as a consequence of NLRP3 inflammasome activation. This evidence concerns the gene NLRP3 and neoplasm.