It was discovered that both Palmitoleic Acid (POA) (0.6–3.2%) and oleic acid modulate insulin sensitivity, albeit through different mechanisms, by raising circulating levels of adiponectin and omentin and lowering inflammation markers in a study that looked at the effects of these substances on lipid metabolism, inflammation, and insulin sensitivity in a male rat model that is not obese but has prediabetic hereditary hypertriglyceridemia. The gene discussed is ADIPOQ; the disease is hypertriglyceridemia.